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igf1 receptor inhibitor experiment  (MedChemExpress)


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    MedChemExpress igf1 receptor inhibitor experiment
    The role of <t>IGF1</t> in ALF mice with MSC treatment (A) Immunofluorescence staining of the macrophage marker CD11b in the liver. The magnification is 1000× and 3000×. (B) Serum IGF1 expression was detected by ELISA. (C) Immunohistochemical staining of IGF-1R proteins in the NC, CCL4+PBS, and CCL4+MSC groups (n=3). The magnification is 100×. (D) The survival curves of mice in each group. (E,F) The levels of MDA and GSH were measured. (G) Immunolocalization of Ptgs2 and Gpx4 proteins in the NC, CCL4+PBS, and CCL4+MSC groups (n=3). The magnification is 100×. Data are expressed as the mean±SEM. ns: no significant difference. *P<0.05, **P<0.01, and ***P<0.001.
    Igf1 Receptor Inhibitor Experiment, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/igf1+receptor+inhibitor+experiment/IGF-1R+inhibitor-2/pmc10984864-62-2-12
    Average 93 stars, based on 6 article reviews
    igf1 receptor inhibitor experiment - by Bioz Stars, 2026-09
    93/100 stars

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    1) Product Images from "Human umbilical cord mesenchymal stem cells protect against ferroptosis in acute liver failure through the IGF1-hepcidin-FPN1 axis and inhibiting iron loading"

    Article Title: Human umbilical cord mesenchymal stem cells protect against ferroptosis in acute liver failure through the IGF1-hepcidin-FPN1 axis and inhibiting iron loading

    Journal: Acta Biochimica et Biophysica Sinica

    doi: 10.3724/abbs.2023275

    The role of IGF1 in ALF mice with MSC treatment (A) Immunofluorescence staining of the macrophage marker CD11b in the liver. The magnification is 1000× and 3000×. (B) Serum IGF1 expression was detected by ELISA. (C) Immunohistochemical staining of IGF-1R proteins in the NC, CCL4+PBS, and CCL4+MSC groups (n=3). The magnification is 100×. (D) The survival curves of mice in each group. (E,F) The levels of MDA and GSH were measured. (G) Immunolocalization of Ptgs2 and Gpx4 proteins in the NC, CCL4+PBS, and CCL4+MSC groups (n=3). The magnification is 100×. Data are expressed as the mean±SEM. ns: no significant difference. *P<0.05, **P<0.01, and ***P<0.001.
    Figure Legend Snippet: The role of IGF1 in ALF mice with MSC treatment (A) Immunofluorescence staining of the macrophage marker CD11b in the liver. The magnification is 1000× and 3000×. (B) Serum IGF1 expression was detected by ELISA. (C) Immunohistochemical staining of IGF-1R proteins in the NC, CCL4+PBS, and CCL4+MSC groups (n=3). The magnification is 100×. (D) The survival curves of mice in each group. (E,F) The levels of MDA and GSH were measured. (G) Immunolocalization of Ptgs2 and Gpx4 proteins in the NC, CCL4+PBS, and CCL4+MSC groups (n=3). The magnification is 100×. Data are expressed as the mean±SEM. ns: no significant difference. *P<0.05, **P<0.01, and ***P<0.001.

    Techniques Used: Immunofluorescence, Staining, Marker, Expressing, Enzyme-linked Immunosorbent Assay, Immunohistochemical staining

    The role of IGF1 in iron deposition in ALF mice treated with MSCs (A) The level of iron in the liver was measured. (B) Representative images of Prussian blue iron staining. The magnification is 100×. (C) Immunolocalization of hepcidin protein in each group. The magnification is 100×. The MOD of hepcidin protein was calculated from 3 stained pictures of three mice in each group. (D) Western blot analysis of hepcidin and FPN1 protein levels in each group (n=3). Data are expressed as the mean±SEM. ns: no significant difference. *P<0.05, **P<0.01, and ***P<0.001.
    Figure Legend Snippet: The role of IGF1 in iron deposition in ALF mice treated with MSCs (A) The level of iron in the liver was measured. (B) Representative images of Prussian blue iron staining. The magnification is 100×. (C) Immunolocalization of hepcidin protein in each group. The magnification is 100×. The MOD of hepcidin protein was calculated from 3 stained pictures of three mice in each group. (D) Western blot analysis of hepcidin and FPN1 protein levels in each group (n=3). Data are expressed as the mean±SEM. ns: no significant difference. *P<0.05, **P<0.01, and ***P<0.001.

    Techniques Used: Staining, Western Blot

    Related Articles

    Immunofluorescence:

    Article Title: Human umbilical cord mesenchymal stem cells protect against ferroptosis in acute liver failure through the IGF1-hepcidin-FPN1 axis and inhibiting iron loading
    Article Snippet: 5 MSCs in 100 μL PBS via the tail vein after 3 h. Mice were sacrificed on day 3, and liver and serum samples were collected for further analysis. .. For the IGF1 receptor inhibitor experiment, the IGF1 receptor inhibitor picropodophyllin (PPP; MedChemExpress, Monmouth Junction, USA) was utilized. .. The mice were randomly divided into four groups ( n =10 mice per group): the negative control group (NC), the ALF group (CCL 4 +PBS+vehicle), the MSC

    Article Title: Mesenchymal stromal cells ameliorate hyperammonemia via IGF1-IGF1R- GLS2 axis inhibiting glutaminolysis in acute hepatic failure
    Article Snippet: mice were euthanized with urethane (0.8 g/kg) and mouse liver tissue is409 collected, fixation of the left lobe of the liver in 4% paraformaldehyde. .. The remaining collected410 liver tissue was divided into tubes and placed in liquid nitrogen for flash freezing, and then stored at411 -80 °C for long-term storage.412 For the IGF1 receptor inhibitor experiment, the IGF1 receptor inhibitor Picropodophyllin (PPP,413 MedChemExpress)(MedChemExpress, America) was applied. .. Mice received 1.25 ml/kg CCL4 via414 i.p. injection in all experimental groups.

    Staining:

    Article Title: Human umbilical cord mesenchymal stem cells protect against ferroptosis in acute liver failure through the IGF1-hepcidin-FPN1 axis and inhibiting iron loading
    Article Snippet: 5 MSCs in 100 μL PBS via the tail vein after 3 h. Mice were sacrificed on day 3, and liver and serum samples were collected for further analysis. .. For the IGF1 receptor inhibitor experiment, the IGF1 receptor inhibitor picropodophyllin (PPP; MedChemExpress, Monmouth Junction, USA) was utilized. .. The mice were randomly divided into four groups ( n =10 mice per group): the negative control group (NC), the ALF group (CCL 4 +PBS+vehicle), the MSC

    Article Title: Mesenchymal stromal cells ameliorate hyperammonemia via IGF1-IGF1R- GLS2 axis inhibiting glutaminolysis in acute hepatic failure
    Article Snippet: mice were euthanized with urethane (0.8 g/kg) and mouse liver tissue is409 collected, fixation of the left lobe of the liver in 4% paraformaldehyde. .. The remaining collected410 liver tissue was divided into tubes and placed in liquid nitrogen for flash freezing, and then stored at411 -80 °C for long-term storage.412 For the IGF1 receptor inhibitor experiment, the IGF1 receptor inhibitor Picropodophyllin (PPP,413 MedChemExpress)(MedChemExpress, America) was applied. .. Mice received 1.25 ml/kg CCL4 via414 i.p. injection in all experimental groups.

    Marker:

    Article Title: Human umbilical cord mesenchymal stem cells protect against ferroptosis in acute liver failure through the IGF1-hepcidin-FPN1 axis and inhibiting iron loading
    Article Snippet: 5 MSCs in 100 μL PBS via the tail vein after 3 h. Mice were sacrificed on day 3, and liver and serum samples were collected for further analysis. .. For the IGF1 receptor inhibitor experiment, the IGF1 receptor inhibitor picropodophyllin (PPP; MedChemExpress, Monmouth Junction, USA) was utilized. .. The mice were randomly divided into four groups ( n =10 mice per group): the negative control group (NC), the ALF group (CCL 4 +PBS+vehicle), the MSC

    Article Title: Mesenchymal stromal cells ameliorate hyperammonemia via IGF1-IGF1R- GLS2 axis inhibiting glutaminolysis in acute hepatic failure
    Article Snippet: mice were euthanized with urethane (0.8 g/kg) and mouse liver tissue is409 collected, fixation of the left lobe of the liver in 4% paraformaldehyde. .. The remaining collected410 liver tissue was divided into tubes and placed in liquid nitrogen for flash freezing, and then stored at411 -80 °C for long-term storage.412 For the IGF1 receptor inhibitor experiment, the IGF1 receptor inhibitor Picropodophyllin (PPP,413 MedChemExpress)(MedChemExpress, America) was applied. .. Mice received 1.25 ml/kg CCL4 via414 i.p. injection in all experimental groups.

    Expressing:

    Article Title: Human umbilical cord mesenchymal stem cells protect against ferroptosis in acute liver failure through the IGF1-hepcidin-FPN1 axis and inhibiting iron loading
    Article Snippet: 5 MSCs in 100 μL PBS via the tail vein after 3 h. Mice were sacrificed on day 3, and liver and serum samples were collected for further analysis. .. For the IGF1 receptor inhibitor experiment, the IGF1 receptor inhibitor picropodophyllin (PPP; MedChemExpress, Monmouth Junction, USA) was utilized. .. The mice were randomly divided into four groups ( n =10 mice per group): the negative control group (NC), the ALF group (CCL 4 +PBS+vehicle), the MSC

    Article Title: Mesenchymal stromal cells ameliorate hyperammonemia via IGF1-IGF1R- GLS2 axis inhibiting glutaminolysis in acute hepatic failure
    Article Snippet: mice were euthanized with urethane (0.8 g/kg) and mouse liver tissue is409 collected, fixation of the left lobe of the liver in 4% paraformaldehyde. .. The remaining collected410 liver tissue was divided into tubes and placed in liquid nitrogen for flash freezing, and then stored at411 -80 °C for long-term storage.412 For the IGF1 receptor inhibitor experiment, the IGF1 receptor inhibitor Picropodophyllin (PPP,413 MedChemExpress)(MedChemExpress, America) was applied. .. Mice received 1.25 ml/kg CCL4 via414 i.p. injection in all experimental groups.

    Enzyme-linked Immunosorbent Assay:

    Article Title: Human umbilical cord mesenchymal stem cells protect against ferroptosis in acute liver failure through the IGF1-hepcidin-FPN1 axis and inhibiting iron loading
    Article Snippet: 5 MSCs in 100 μL PBS via the tail vein after 3 h. Mice were sacrificed on day 3, and liver and serum samples were collected for further analysis. .. For the IGF1 receptor inhibitor experiment, the IGF1 receptor inhibitor picropodophyllin (PPP; MedChemExpress, Monmouth Junction, USA) was utilized. .. The mice were randomly divided into four groups ( n =10 mice per group): the negative control group (NC), the ALF group (CCL 4 +PBS+vehicle), the MSC

    Article Title: Mesenchymal stromal cells ameliorate hyperammonemia via IGF1-IGF1R- GLS2 axis inhibiting glutaminolysis in acute hepatic failure
    Article Snippet: mice were euthanized with urethane (0.8 g/kg) and mouse liver tissue is409 collected, fixation of the left lobe of the liver in 4% paraformaldehyde. .. The remaining collected410 liver tissue was divided into tubes and placed in liquid nitrogen for flash freezing, and then stored at411 -80 °C for long-term storage.412 For the IGF1 receptor inhibitor experiment, the IGF1 receptor inhibitor Picropodophyllin (PPP,413 MedChemExpress)(MedChemExpress, America) was applied. .. Mice received 1.25 ml/kg CCL4 via414 i.p. injection in all experimental groups.

    Immunohistochemical staining:

    Article Title: Human umbilical cord mesenchymal stem cells protect against ferroptosis in acute liver failure through the IGF1-hepcidin-FPN1 axis and inhibiting iron loading
    Article Snippet: 5 MSCs in 100 μL PBS via the tail vein after 3 h. Mice were sacrificed on day 3, and liver and serum samples were collected for further analysis. .. For the IGF1 receptor inhibitor experiment, the IGF1 receptor inhibitor picropodophyllin (PPP; MedChemExpress, Monmouth Junction, USA) was utilized. .. The mice were randomly divided into four groups ( n =10 mice per group): the negative control group (NC), the ALF group (CCL 4 +PBS+vehicle), the MSC

    Article Title: Mesenchymal stromal cells ameliorate hyperammonemia via IGF1-IGF1R- GLS2 axis inhibiting glutaminolysis in acute hepatic failure
    Article Snippet: mice were euthanized with urethane (0.8 g/kg) and mouse liver tissue is409 collected, fixation of the left lobe of the liver in 4% paraformaldehyde. .. The remaining collected410 liver tissue was divided into tubes and placed in liquid nitrogen for flash freezing, and then stored at411 -80 °C for long-term storage.412 For the IGF1 receptor inhibitor experiment, the IGF1 receptor inhibitor Picropodophyllin (PPP,413 MedChemExpress)(MedChemExpress, America) was applied. .. Mice received 1.25 ml/kg CCL4 via414 i.p. injection in all experimental groups.

    Western Blot:

    Article Title: Human umbilical cord mesenchymal stem cells protect against ferroptosis in acute liver failure through the IGF1-hepcidin-FPN1 axis and inhibiting iron loading
    Article Snippet: 5 MSCs in 100 μL PBS via the tail vein after 3 h. Mice were sacrificed on day 3, and liver and serum samples were collected for further analysis. .. For the IGF1 receptor inhibitor experiment, the IGF1 receptor inhibitor picropodophyllin (PPP; MedChemExpress, Monmouth Junction, USA) was utilized. .. The mice were randomly divided into four groups ( n =10 mice per group): the negative control group (NC), the ALF group (CCL 4 +PBS+vehicle), the MSC

    Article Title: Mesenchymal stromal cells ameliorate hyperammonemia via IGF1-IGF1R- GLS2 axis inhibiting glutaminolysis in acute hepatic failure
    Article Snippet: mice were euthanized with urethane (0.8 g/kg) and mouse liver tissue is409 collected, fixation of the left lobe of the liver in 4% paraformaldehyde. .. The remaining collected410 liver tissue was divided into tubes and placed in liquid nitrogen for flash freezing, and then stored at411 -80 °C for long-term storage.412 For the IGF1 receptor inhibitor experiment, the IGF1 receptor inhibitor Picropodophyllin (PPP,413 MedChemExpress)(MedChemExpress, America) was applied. .. Mice received 1.25 ml/kg CCL4 via414 i.p. injection in all experimental groups.



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    igf1 receptor inhibitor experiment  (MedChemExpress)
    93
    MedChemExpress igf1 receptor inhibitor experiment
    The role of <t>IGF1</t> in ALF mice with MSC treatment (A) Immunofluorescence staining of the macrophage marker CD11b in the liver. The magnification is 1000× and 3000×. (B) Serum IGF1 expression was detected by ELISA. (C) Immunohistochemical staining of IGF-1R proteins in the NC, CCL4+PBS, and CCL4+MSC groups (n=3). The magnification is 100×. (D) The survival curves of mice in each group. (E,F) The levels of MDA and GSH were measured. (G) Immunolocalization of Ptgs2 and Gpx4 proteins in the NC, CCL4+PBS, and CCL4+MSC groups (n=3). The magnification is 100×. Data are expressed as the mean±SEM. ns: no significant difference. *P<0.05, **P<0.01, and ***P<0.001.
    Igf1 Receptor Inhibitor Experiment, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/igf1+receptor+inhibitor+experiment/IGF-1R+inhibitor-2/pmc10984864-62-2-12
    Average 93 stars, based on 1 article reviews
    igf1 receptor inhibitor experiment - by Bioz Stars, 2026-09
    93/100 stars
    		  Buy from Supplier

    Image Search Results


    The role of IGF1 in ALF mice with MSC treatment (A) Immunofluorescence staining of the macrophage marker CD11b in the liver. The magnification is 1000× and 3000×. (B) Serum IGF1 expression was detected by ELISA. (C) Immunohistochemical staining of IGF-1R proteins in the NC, CCL4+PBS, and CCL4+MSC groups (n=3). The magnification is 100×. (D) The survival curves of mice in each group. (E,F) The levels of MDA and GSH were measured. (G) Immunolocalization of Ptgs2 and Gpx4 proteins in the NC, CCL4+PBS, and CCL4+MSC groups (n=3). The magnification is 100×. Data are expressed as the mean±SEM. ns: no significant difference. *P<0.05, **P<0.01, and ***P<0.001.

    Journal: Acta Biochimica et Biophysica Sinica

    Article Title: Human umbilical cord mesenchymal stem cells protect against ferroptosis in acute liver failure through the IGF1-hepcidin-FPN1 axis and inhibiting iron loading

    doi: 10.3724/abbs.2023275

    Figure Lengend Snippet: The role of IGF1 in ALF mice with MSC treatment (A) Immunofluorescence staining of the macrophage marker CD11b in the liver. The magnification is 1000× and 3000×. (B) Serum IGF1 expression was detected by ELISA. (C) Immunohistochemical staining of IGF-1R proteins in the NC, CCL4+PBS, and CCL4+MSC groups (n=3). The magnification is 100×. (D) The survival curves of mice in each group. (E,F) The levels of MDA and GSH were measured. (G) Immunolocalization of Ptgs2 and Gpx4 proteins in the NC, CCL4+PBS, and CCL4+MSC groups (n=3). The magnification is 100×. Data are expressed as the mean±SEM. ns: no significant difference. *P<0.05, **P<0.01, and ***P<0.001.

    Article Snippet: For the IGF1 receptor inhibitor experiment, the IGF1 receptor inhibitor picropodophyllin (PPP; MedChemExpress, Monmouth Junction, USA) was utilized.

    Techniques: Immunofluorescence, Staining, Marker, Expressing, Enzyme-linked Immunosorbent Assay, Immunohistochemical staining

    The role of IGF1 in iron deposition in ALF mice treated with MSCs (A) The level of iron in the liver was measured. (B) Representative images of Prussian blue iron staining. The magnification is 100×. (C) Immunolocalization of hepcidin protein in each group. The magnification is 100×. The MOD of hepcidin protein was calculated from 3 stained pictures of three mice in each group. (D) Western blot analysis of hepcidin and FPN1 protein levels in each group (n=3). Data are expressed as the mean±SEM. ns: no significant difference. *P<0.05, **P<0.01, and ***P<0.001.

    Journal: Acta Biochimica et Biophysica Sinica

    Article Title: Human umbilical cord mesenchymal stem cells protect against ferroptosis in acute liver failure through the IGF1-hepcidin-FPN1 axis and inhibiting iron loading

    doi: 10.3724/abbs.2023275

    Figure Lengend Snippet: The role of IGF1 in iron deposition in ALF mice treated with MSCs (A) The level of iron in the liver was measured. (B) Representative images of Prussian blue iron staining. The magnification is 100×. (C) Immunolocalization of hepcidin protein in each group. The magnification is 100×. The MOD of hepcidin protein was calculated from 3 stained pictures of three mice in each group. (D) Western blot analysis of hepcidin and FPN1 protein levels in each group (n=3). Data are expressed as the mean±SEM. ns: no significant difference. *P<0.05, **P<0.01, and ***P<0.001.

    Article Snippet: For the IGF1 receptor inhibitor experiment, the IGF1 receptor inhibitor picropodophyllin (PPP; MedChemExpress, Monmouth Junction, USA) was utilized.

    Techniques: Staining, Western Blot